Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells
نویسندگان
چکیده
منابع مشابه
Studies on Focal Adhesion Kinase in Human Breast Cancer Tissue
Aim: To study Expression and Phosphorylation status of Focal Adhesion Kinase (FAK) in Human Breast Cancer tissue. To study the relation of FAK with standard clinicopathological parameters of Human Breast Cancer. Methods: Tissue collection, Protein extraction, RNA isolation, Western Blot, Immunohistochemistry, RT-PCR, ELISA, Statistical analysis. Results: All the four techniques showed upregulat...
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Triptolide, a diterpene from Tripterygium wilfordii, has been shown to have potent anticancer activity, exerting its effects through multiple molecular targets and signaling pathways. Yet, its effect on focal adhesion kinase (FAK), a non-receptor tyrosine kinase overexpressed in breast cancer that regulates cellular adhesion and survival, has not been reported. The current study is the first to...
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ژورنال
عنوان ژورنال: Cell Chemical Biology
سال: 2019
ISSN: 2451-9456
DOI: 10.1016/j.chembiol.2019.03.016